Ginzburg was born in Tel Aviv, Israel. Her father, Arieh Ginzburg, is an architect, and her grandfather was involved in the original planning and construction of Zahala Tel Aviv. Ginzburg is Jewish. On June 8, 2012, Ginzburg married the real estate investor Adi Keizman.
Ginzburg started modeling at the age of eight with a milk advertisement and at the age of 14 signed a contract with modeling agency Elite Models. In 2006, she signed a two-year deal with Israeli firm Fox, replacing four-year covergirl Yael Bar Zohar and was featured on the February/March 2007 cover of French ELLE. She has also modeled for brands like Tommy Hilfiger, Burberry, FCUK, Pull and Bear, and Castro. She was also featured in the 2009, 2010, and 2011 Sports Illustrated Swimsuit Issue. Ginzburg made her acting debut in the 2010 Joel Schumacher film Twelve.
Ginzburg currently resides in Tel Aviv. She was drafted into the army (IDF) on 22 July 2009, and in early October of that year, while speaking in support of enlisting, caused headlines by criticizing fellow Israeli model Bar Rafaeli for avoiding military service via a short-lived marriage to a family friend. On joining the army Ginzburg said: "Military service is part of the things I personally believe in."
